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662 A/G gene variation in human tumor necrosis factor receptor superfamily, member 9 (TNFRSF9)
QU Yanchun, YANG Ze, SUN Liang, JI Linong
《医学前沿(英文)》 2008年 第2卷 第3期 页码 283-285 doi: 10.1007/s11684-008-0053-7
关键词: D-HPLC mutation development autoimmune PCR-RFLP candidate
Freshwater algae chemotaxonomy by high-performance liquid chromatographic (HPLC) analysis
Yansong HOU, Wei LIANG, Liping ZHANG, Shuiping CHENG, Feng HE, Zhenbin WU
《环境科学与工程前沿(英文)》 2011年 第5卷 第1期 页码 84-91 doi: 10.1007/s11783-010-0283-1
关键词: high-performance liquid chromatographic (HPLC) algae pigment chemotaxonomy
Novel mutation c.1210-3C>G in with a poly-T tract of 5T affects mRNA splicing in a Chinese patient
《医学前沿(英文)》 2022年 第16卷 第1期 页码 150-155 doi: 10.1007/s11684-021-0846-5
AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches
null
《医学前沿(英文)》 2012年 第6卷 第3期 页码 248-262 doi: 10.1007/s11684-012-0206-6
The AML1-ETO fusion transcription factor is generated by the t(8;21) translocation, which is present in approximately 4%–12% of adult and 12%–30% of pediatric acute myeloid leukemia (AML) patients. Both human and mouse models of AML have demonstrated that AML1-ETO is insufficient for leukemogenesis in the absence of secondary events. In this review, we discuss the pathogenetic insights that have been gained from identifying the various events that can cooperate with AML1-ETO to induce AML in vivo. We also discuss potential therapeutic strategies for t(8;21) positive AML that involve targeting the fusion protein itself, the proteins that bind to it, or the genes that it regulates. Recently published studies suggest that a targeted therapy for t(8;21) positive AML is feasible and may be coming sometime soon.
关键词: AML1-ETO mouse model leukemia t(8 21) pathway hits mutation hematopoiesis Kasumi-1 CD34+
HPLC determination of glyoxal in aldehyde solution with 3-methyl-2-benzothiazolinone hydrazone
Yamei ZHU, Xiaoli YAO, Shaohui CHEN, Qun CUI, Haiyan WANG
《化学科学与工程前沿(英文)》 2011年 第5卷 第1期 页码 117-121 doi: 10.1007/s11705-010-0535-4
关键词: HPLC glyoxal 3-methyl-2-benzothiazolinone hydrazone diazine dicarbonyl compounds
Mutation profiling of 16 candidate genes in
Yang Zhang, Fang Wang, Xue Chen, Wenjing Liu, Jiancheng Fang, Mingyu Wang, Wen Teng, Panxiang Cao, Hongxing Liu
《医学前沿(英文)》 2019年 第13卷 第2期 页码 229-237 doi: 10.1007/s11684-018-0616-1
于德泉
《中国工程科学》 1999年 第1卷 第2期 页码 87-90
文章展望了从天然产物中创制新药的发展趋势。单味中草药有效成分的研究重点将转向瞄准质控的中药复方化学成分研究。进入21世纪,中国天然药物研究要在国际上占有重要位置,突破口便是中药复方现代化,其关键之一便是化学(有效)成分研究。从中草药中发现有效成分或先导物必须采用化学成分与生物活性研究融为一体的机制,采用高通量筛选,目标就是寻找有效成分或先导物进而创制新药。长短结合,正确处理知识创新和新药开发的关系。知识创新须体现在创制新药的应用基础研究中,是产生巨大效益的理论基础;短程开发是知识累积水平的体现,是科研经费的必要补充和保证。改革传统天然产物化学研究模式,实施以当代最先进大型谱仪为先导的天然产物研究战略。
WANG Shurong, LUO Zhongyang, CEN Kefa, ZHUANG Xinshu
《能源前沿(英文)》 2008年 第2卷 第3期 页码 268-272 doi: 10.1007/s11708-008-0046-x
关键词: HPLC oligosaccharide lignocellulosic chromatography reducing
NRTIs’ effect on the sequence of mitochondrial DNA HV 2 in HIV infected patients
Ya-Song WU MD, PhD, Xin-Yue CHEN MD, Ying SHI PhD, Hao WU MD, De-Xi CHEN MD, PhD, Yu SUN MD, Fu-Jie ZHANG MD,
《医学前沿(英文)》 2010年 第4卷 第2期 页码 177-184 doi: 10.1007/s11684-010-0038-1
关键词: nucleoside reverse transcriptase inhibitors human immunodeficiency virus mitochondrial DNA D loop mutation
《医学前沿(英文)》 2022年 第16卷 第4期 页码 627-636 doi: 10.1007/s11684-020-0815-4
关键词: RUNX1 gene mutation acute myeloid leukemia transcriptional repression DNA methylation
高尚,杨静宇
《中国工程科学》 2006年 第8卷 第11期 页码 94-98
经典的粒子群是一个有效的寻找连续函数极值的方法,结合遗传算法的思想提出的混合粒子群算法来解决背包问题,经过比较测试,6种混合粒子群算法的效果都比较好,特别交叉策略A和变异策略C的混合粒子群算法是最好的且简单有效的算法,并成功地运用在投资问题中。对于目前还没有好的解法的组合优化问题,很容易地修改此算法就可解决。
Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice
《医学前沿(英文)》 页码 957-971 doi: 10.1007/s11684-023-0988-8
关键词: DNAH10 mice motile cilia mutation primary ciliary dyskinesia
null
《医学前沿(英文)》 2018年 第12卷 第3期 页码 319-323 doi: 10.1007/s11684-017-0553-4
Antithrombin and protein C are two crucial members in the anticoagulant system and play important roles in hemostasis. Mutations in and lead to deficiency or dysfunction of the two proteins, which could result in venous thromboembolism (VTE). Here, we report a Chinese 22-year-old young man who developed recurrent and serious VTE in cerebral veins, visceral veins, and deep veins of the lower extremity. Laboratory tests and direct sequencing of and were conducted for the patient and his family members. Coagulation tests revealed that the patient presented type I antithrombin deficiency combined with decreased protein C activity resulting from a small insertion mutation c.848_849insGATGT in and a short deletion variant c.572_574delAGA in . This combination of the two mutations was absent in 400 healthy subjects each from southern and northern China. Then, we summarized all the mutations of the and gene reported in the Chinese Han population. This study demonstrates that the combination of antithrombin deficiency and decreased protein C activity can result in severe VTE and that the coexistence of different genetic factors may increase the risk of VTE.
关键词: antithrombin deficiency protein C activity mutation variant venous thromboembolism anticoagulants
Analysis of two new degradation products of arsenic triglutathione in aqueous solution
Feng ZHAO, Yuchen CHEN, Bin QIAO, Jing WANG, Ping NA
《化学科学与工程前沿(英文)》 2012年 第6卷 第3期 页码 292-300 doi: 10.1007/s11705-012-1208-2
使用2D、3D和4D增材制造材料开发生物植入物 Review
刘果, 何云虎, 刘朋超, 陈舟, 陈绪梁, 万镭, 李莹, 吕坚
《工程(英文)》 2020年 第6卷 第11期 页码 1232-1243 doi: 10.1016/j.eng.2020.04.015
标题 作者 时间 类型 操作
662 A/G gene variation in human tumor necrosis factor receptor superfamily, member 9 (TNFRSF9)
QU Yanchun, YANG Ze, SUN Liang, JI Linong
期刊论文
Freshwater algae chemotaxonomy by high-performance liquid chromatographic (HPLC) analysis
Yansong HOU, Wei LIANG, Liping ZHANG, Shuiping CHENG, Feng HE, Zhenbin WU
期刊论文
Novel mutation c.1210-3C>G in with a poly-T tract of 5T affects mRNA splicing in a Chinese patient
期刊论文
AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches
null
期刊论文
HPLC determination of glyoxal in aldehyde solution with 3-methyl-2-benzothiazolinone hydrazone
Yamei ZHU, Xiaoli YAO, Shaohui CHEN, Qun CUI, Haiyan WANG
期刊论文
Mutation profiling of 16 candidate genes in
Yang Zhang, Fang Wang, Xue Chen, Wenjing Liu, Jiancheng Fang, Mingyu Wang, Wen Teng, Panxiang Cao, Hongxing Liu
期刊论文
Experimental study and product analysis of lignocellulosic biomass hydrolysis under extremely low acids
WANG Shurong, LUO Zhongyang, CEN Kefa, ZHUANG Xinshu
期刊论文
NRTIs’ effect on the sequence of mitochondrial DNA HV 2 in HIV infected patients
Ya-Song WU MD, PhD, Xin-Yue CHEN MD, Ying SHI PhD, Hao WU MD, De-Xi CHEN MD, PhD, Yu SUN MD, Fu-Jie ZHANG MD,
期刊论文
Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation in acute myeloid leukemia
期刊论文
Antithrombin deficiency and decreased protein C activity in a young man with venous thromboembolism: a case report
null
期刊论文
Analysis of two new degradation products of arsenic triglutathione in aqueous solution
Feng ZHAO, Yuchen CHEN, Bin QIAO, Jing WANG, Ping NA
期刊论文